In 1827–1828 Edinburgh, demand for cadavers for anatomical study far outstripped the legal supply, which under Scottish law was restricted to the bodies of executed prisoners, suicides, and foundlings or orphans. This shortage fuelled a trade in bodies illegally exhumed by "resurrection men," and families increasingly protected graves with mortsafes and watchtowers. Anatomist Robert Knox, who had built a large and successful anatomy lecture practice in Edinburgh, was among those purchasing cadavers with few questions asked.
William Burke, an Irish-born labourer and cobbler, lodged with his partner Helen McDougal at a house in Tanner's Close run by William Hare and Hare's partner Margaret Laird. When a lodger named Donald died owing rent in November 1827, Hare and Burke sold his body to Knox for £7 10s. After this transaction, Hare's household turned to killing lodgers who were ill, elderly, or otherwise vulnerable, smothering them to leave few marks and selling the bodies to Knox, typically for £8 to £10 each. Victims included a miller, a salt-seller named Abigail Simpson, two women named Mary Paterson and Janet Brown's companion, an elderly woman and her deaf grandson, a washerwoman, a relative of McDougal's, and James Wilson, a well-known disabled Edinburgh man called "Daft Jamie." In total, sixteen people were killed over about ten months, most through suffocation carried out by Hare while Burke restrained the victim.
The murders were uncovered when lodgers Ann and James Gray discovered the body of the final victim, Margaret Docherty, hidden in straw at Burke's lodging on 1 November 1828, and alerted police. Docherty's body was recovered from Knox's dissecting rooms. A forensic examination by police surgeon Alexander Black and later specialists Robert Christison and William Newbigging concluded that suffocation was probable but could not be medically proven. Burke, McDougal, Hare, and Margaret Laird were arrested. Because evidence against any single suspect was limited, the Lord Advocate offered Hare immunity from prosecution in exchange for a full confession implicating the others; his wife was also exempted since a spouse could not be compelled to testify against another. Hare confessed to all sixteen deaths, and formal murder charges were brought against Burke and McDougal for three killings: those of Mary Paterson, James Wilson, and Margaret Docherty.
At trial before the High Court of Justiciary, which opened on Christmas Eve 1828 and ran through the night, the indictment was split so that only the Docherty charge was tried first. On Christmas Day 1828 the jury found Burke guilty of murdering Docherty; the same charge against McDougal was found not proven, a Scottish verdict of acquittal. Burke was sentenced to death, his corpse ordered to be publicly dissected. He was hanged on 28 January 1829 before a large crowd, and his skeleton remains on display at the Anatomical Museum of the Edinburgh Medical School. Hare was released in February 1829 and left Edinburgh; his later fate is unknown. Knox faced no charges — Burke's statement exonerated him — though a committee of inquiry examined his conduct and public opinion largely blamed him. The case contributed to the passage of the Anatomy Act 1832 in Britain, which reformed the legal supply of bodies for medical dissection.